The GMP Unit ensures that the Hevesy Laboratory is a fully qualified/validated QC (Quality Control Laboratory) with a GMP (Good Manufacturing Practices) compliant organization.
The Hevesy Laboratory offer reactor produced radioactive isotopes for research and technical purposes.
These isotopes are produced by neutron irradiation of target materials at different reactors in Europe and the US. The irradiated materials are returned to DTU Health Tech, where they are processed, before the final products are distributed to customers in Denmark and abroad.
The routine production of Cu-64 is performed at the cyclotron and beamline facility at the Hevesy Laboratory. The isotope is produced in a (p,n) reaction by irradiating a solid enriched (99%) Ni-64 metal target with a 16 MeV proton beam. After the irradiation (duration 3 to 4 hours) the target is transferred to the laboratory for further processing. Chemical separation ensures that carrier-free Cu-64 is separated from the Ni-64 target material. A typical yield of Cu-64 after separation is 1.5 GBq.
An ongoing project is aiming at producing Cu-64 on a high-activity scale (5 – 10 GBq after chemical separation). For this purpose a so-called High Power Target that resists proton beam currents up to 200 µA has been developed. Such a high proton current reduces the irradiation time drastically and an activity of 10GBq of Cu-64 is easily reached within a few minutes of irradiation time.
These high activity levels of Cu-64 are difficult to handle safely in the laboratory without exposing the staff to a too high radiation dose. The present project therefore also includes the set up of an automation facility for the chemical separation process.