In his latest work presented at IEEE IUS 2025, Lauge N. Hansen and collaborators introduce a parameter-free projection method to improve validation of super-resolution ultrasound (SRUS) using micro-CT data.
The study proposes an ultrasound-field-weighted CT projection that accounts for the simulated ultrasound energy distribution when generating maximum intensity projections (MIPs). This approach enables direct, quantitative comparison between contrast-free SRUS and micro-CT images.
Using rat kidney data, the method achieved a 97.2% structural similarity (SSIM) between the weighted CT projection and the best-matched equidistant MIP, confirming that the new framework produces images quantitatively equivalent to SRUS reconstructions.
This cross-modality registration framework establishes a robust foundation for quantitative validation of super-resolution ultrasound against high-resolution micro-CT data.
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