PhD project by Philip Mark Lund

Name: Philip Mark Lund
Project Title: Mechanistic understanding of peptide binding and translocation across native like membrane model systems
Group:  The Colloids & Biological Interface Group (CBIO)
Supervisors: Jannik Bruun Larsen, Jens Bæk Simonsen and Thomas Lars Andresen.

Project Description:
Oral drug delivery harbors great promise with properties of low administration requirements on both health personal and patients. However with the current oral drug delivery methods, only a small fraction of the administered biopharmaceutical peptides(BP) e.g. insulin reach the blood stream, due to low absorption in the small intestines. The objective of this project is to shed light on the translocation mechanism of BPs across epithelial cells. Here I will utilize a state of the art custom build lattice light sheet microscope with adaptive optics for fluorescent microscopy for biophysical in vitro assays. The assays range from simple lipid systems to complex cellular models, will lay the foundation for unveiling the translocation mechanistic of BPs and what specific modifications may alter.

Perspective:
By understanding the mechanism by which BP translocation across the epithelial cell barrier grants the opportunity of developing orally administered peptide drugs. Chronically sick patients such as diabetics require injections day causing discomfort and in worst cases infections. Developing an orally available alternative will increase the patient compliance, reduce cost for health personal and possibility increase shell life.

 

Kontakt

Philip Mark Lund
Ph.d.-studerende
DTU Sundhedsteknologi

Kontakt

Jannik Larsen
Adjunkt
DTU Sundhedsteknologi
45 25 81 23

Kontakt

Jens Bæk Simonsen
Gæst
DTU Sundhedsteknologi

Kontakt

Thomas Lars Andresen
Professor
DTU Sundhedsteknologi
25 37 44 86