PhD scholarship in Hyperpolarization of Water for Angiography and Perfusion

fredag 24 jan 20

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Frist 28. februar 2020
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Hyperpolarized Magnetic Resonance is a new medical imaging modality with great potential. The method is enabled by the more than 100,000-fold enhancement of the signal from nuclear spins. It offers the possibility of studying disease at the biochemical level, allowing more accurate diagnosis and treatment for the individual patient.

The PhD project is part of a EU FET Open funded consortium targeting alternatives to conventional Gadolinium based MR contrast agents for angiography and perfusion imaging. The consortium pursues several approaches, but this PhD project specifically aims to develop and study hyperpolarized water by dissolution Dynamic Nuclear Polarization for perfusion and angiography. Hyperpolarized water can provide a signal that is several orders of magnitude stronger than the tissue signal, and could enable superior angiograph and perfusion imaging. The key idea in the project is to study formulations of the hyperpolarized water that can extend the relaxation time of the water protons after injection into the blood stream, e.g. through micro-emulsions. This would shift hyperpolarized water from being an invasive, intra-arterial method to becoming equivalent in use to conventional MR contrast agents as a non-invasive, intravenous agent.

HYPERMAG is part of the Center for Magnetic Resonance (
www.cmr.healthtech.dtu.dk) that conducts research in MRI and NMR. Our research is conducted in collaboration with universities, hospitals and healthcare companies both nationally and internationally. Our main educational responsibility is within the BSc and MSc program in BioMedical Engineering in collaboration with the Faculty of Health Sciences, University of Copenhagen.

Responsibilities and tasks
You will be responsible for developing formulations that extend the T1 of the water protons and are well-tolerated, e.g. by additives, emulsifiers or containers. High degree of incorporation of the hyperpolarized water and preservation of nuclear spin polarization are key parameters.

You will be responsible for preliminary safety studies of selected formulations as well as validation studies in a pig model of angiography and perfusion. The studies will involve interaction with other consortium members with expertise in formulations of contrast agents and imaging.

You will be part of a larger team at DTU working on the hyperpolarization of water protons and the physics and methodology of dissolution-DNP. 

You should be an outgoing person with enthusiasm, good spirit and be collaborative.

Qualifications
Candidates should have a two-year master's degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master's degree. The preferred candidate has a degree within biomedical engineering, physical chemistry, physics or similar. Basic knowledge of NMR or MRI is a requirement.

Approval and Enrolment
The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see the 
DTU PhD Guide.    

Assessment
The assessment of the applicants will be made by Prof Jan Henrik Ardenkjær-Larsen.  

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and appointment terms
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years.

Workplace is DTU Lyngby Campus.

You can read more about career paths at DTU here.  

Further information
Further information may be obtained from Prof. Jan Ardenkjær-Larsen, tel.: +45 4525 3918.  

You can read more about Center for Magnetic Resonance at  www.cmr.health.dtu.dk


Application
Please submit your online application no later than 28 February 2020 (23:59 local time)Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:  

  • A letter motivating the application (cover letter)
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and Excel spreadsheet here)

Candidates may apply prior to obtaining their master's degree but cannot begin before having received it.

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

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