Postdoc in Synthesis of Metal-Organic Framework Nanoparticles for Drug Delivery Applications

tirsdag 21 jun 22

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Frist 8. juli 2022
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At the Biomimetics, Biocarriers and Bioimplants group (The 3Bs) we are looking for a highly motivated postdoctoral candidate with a strong background in fabrication and characterization of metal-organic framework (MOF)-based nanoparticles (MOF-NPs) for drug delivery applications. 

The 3Bs, which is headed by Assoc. Prof. Leticia HostaRigau at the Department for Health Technology of the Technical University of Denmark (DTU), is a highly interdisciplinary and positive group with openminded and supportive members. The 3Bs research is truly multidisciplinary encompassing materials science, organic/polymer chemistry together with molecular and cell biology. The research focus areas of the group are drug delivery, tissue engineering and cell mimicry.  

For more details on our lab and research please visit: www.healthtech.dtu.dk/3bs

The job
Blood is crucial for our survival and the only way to substitute for blood loss occurring during accidents or surgery is by using blood from donors. However, blood transfusions have some limitations and risks: before blood can be transfused, there is a need for typing and matching due to the different blood groups causing fatal delays in emergency situations. Also, blood has a short storage lifetime, which makes it impossible to create large blood supplies to be used in acute disasters such as earthquakes or plane accidents. Furthermore, blood transfusions can help spreading new viral infections, like it happened with HIV in the 80s.

Thus, developing a new oxygencarrier solution for use when red blood cells (RBCs) are neither an option nor available persists as one of the foremost important challenges in biomedicine.

In this project, which builds on extensive published and unpublished data from The 3Bs group, we will develop a new generation of artificial RBCs to be used in situations where donor blood is not available.

Specifically, we will explore several MOF-NPs (e.g., ZIF8, PCN333 etc) for the encapsulation of hemoglobin and we will investigate their potential to be used as blood substitutes.

For reference, please see: Biomater. Sci., 2021, 9, 1135; ACS Appl. Mater. Interfaces, 2020, 12, 50275; Biomater. Sci., 2020, 8, 5859; J. Colloid Interface Sci., 2020, 571, 326 and ACS Appl. Mater. Interfaces, 2019, 11, 35604.

Responsibilities

  • Fabrication of different MOF-NPs and explore their loading with hemoglobin and other relevant compounds
  • Conduct a thorough physico-chemical characterization employing several techniques (i.e., SEM, TEM, BET, XRD, DLS, FTIR, SAXS, ICP-MS or XPS)
  • Assessment of functionality (e.g., oxygen binding and releasing properties)
  • Contribute to documentation and communication of the expected results

Our expectations from you
As a formal qualification, you must hold a PhD degree (or equivalent) ideally in chemistry or materials science. Specifically, we are looking for a candidate that has demonstrable evidence in the fabrication of different MOFs as well as their characterization by prominent techniques such as XRD, BET, XPS, EDS among others.

Preferable qualifications:

  • Excellent writing skills
  • Research experience in the fields of drug delivery or biomedicine
  • Strong publication record
  • Experience in co-supervising MSc and PhD students

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

The period of employment is initially for 1 year. The position is available immediately.

You can read more about career paths at DTU here.

Further information
Further information can be obtained from Assoc. Prof. Leticia Hosta-Rigau (email: leri@dtu.dk).

You can read more about DTU Health Tech at www.healthtech.dtu.dk/english

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark

Application procedure
Your complete online application must be submitted no later than 8 July 2022 (Danish time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

  • Application (cover letter)
  • CV including employment history, H-Index, citations and ORCID
  • List of publications indicating scientific highlights
  • One-page summary of your PhD thesis
  • Academic Diplomas (MSc/PhD)

Applications received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

DTU Health Tech
DTU Health Tech engages in research, education, and innovation base on technical and natural science for the healthcare sector. The Healthcare sector is a globally expanding market with demands for the most advanced technological solutions. DTU Health Tech creates the foundation for companies to develop new and innovative services and products which benefit people and create value for society. DTU Health Techs expertise spans from imaging and biosensor techniques, across digital health and biological modelling, to biopharma technologies. The department has a scientific staff of about 210 persons, 130 PhD students and a technical/administrative support staff of about 160 persons, of which a large majority contributes to our research infrastructure and related commercial activities.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 13,400 students and 5,800 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.