Postdoc position in Immunology

tirsdag 15 sep 20

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Frist 1. november 2020
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Post-doctoral position in Immunology starting February 1 2021 available at the Technical University of Denmark (DTU), Department of Health Technology, Section of Experimental and Translational Immunology.   

Research Project
The project is titled: Understanding the importance of cIAPs as NF-κB molecular switches in psoriasis.. 

The E3 ubiquitin ligases cIAP1 and cIAP2 (cIAPs) promote the canonical but suppress the non-canonical NF-κB pathway. We have shown before that acute ablation of cIAPs blocks T-helper-17 (Th17) differentiation (see Rizk et al, 2019, Science Signaling), whereas cell-specific genetic deficiency leads to a progressive loss of IL-17-producing gamma delta (γδ) T cells and group 3 innate lymphoid cells (see Rizk et al, 2020, bioRxiv). In this project we aim to investigate: 1) the T cell intrinsic importance of cIAPs in the context of experimental psoriasis, 2) whether cIAP inhibition impacts on (a) disease progression and (b) keratinocyte function.    

Research group and environment
The project will be carried out in the group of Dr Vasileios Bekiaris. At the Department of Health Technology, we have generated a vibrant and very productive research environment in Immunology, with all the required facilities and expertise in most areas of Immunology.

Qualifications

Education

Candidates should hold a PhD in Immunology or relevant discipline.

Research Skills & Expectations
The successful candidate should have demonstrable evidence in multi-parametric flow cytometry, mouse experimentation (FELASA B training or country equivalent is necessary), primary skin (or similar, e.g. gut, liver) cell isolation tehcniques, basic biochemistry and molecular biology. Basic skills in R would be a great advantage.The successful candidate will be able to perform daily experiments with little supervision, contribute to other research activities in the group, participate actively in meetings and seminars and supervise MSc students.  

Personal Skills
We are looking for a post-doc that functions well in a team environment, holds collegial respect to a high standard, is highly motivated and hardworking, and has research excellence as a top priority. Proficient skills in English is necessary.      

Salary and appointment terms
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 2 years. 

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Further information
You can read more about the Department for Health Technology at www.healthtech.dtu.dk/english

Application 
Please submit your online application no later than November 1 2020 (local time)
Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

  • A cover letter (max 500 words)
  • Curriculum vitae (max 2 pages): degrees with dates and place must be clearly stated; only relevant previous work experience must be stated; you should state the contact information of at least two academic referees, one of which must be the PhD supervisor.   
  • A one-page summary of your PhD thesis
  • Publications list (include pre-prints and manuscripts currently under review)

Incomplete applications will not be considered. Applications and enclosures received after the deadline will not be considered. 

All applicants will receive an answer no later than November 15 2020. 

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply.

DTU Health Tech engages in research, education, and innovation base on technical and natural science for the healthcare sector. The Healthcare sector is a globally expanding market with demands for the most advanced technological solutions. DTU Health Tech creates the foundation for companies to develop new and innovative services and products which benefit people and create value for society. DTU Health Techs expertise spans from imaging and biosensor techniques, across digital health and biological modelling, to biopharma technologies. The department has a scientific staff of about 175 persons, 130 PhD students and a technical/administrative support staff of about 80 persons.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 12,000 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. Our main campus is in Kgs. Lyngby north of Copenhagen and we have campuses in Roskilde and Ballerup and in Sisimiut in Greenland.