Emma Christine Jappe

PhD project by Emma Christine Jappe

Name: Emma Christine Jappe
Project Title: Investigating predictive features for peptide immunogenicity in the context of cancer neoepitope immunotherapy
Group: Single Cell Omics
Supervisor(s): Lars Rønn Olsen

Project Description:
The main objective of the PhD project is to the investigate predictive features for peptide immunogenicity in the context of cancer neoepitope immunotherapy. Data generation through mass spectrometry and development of machine learning models to predict peptide immunogenicity features and rank neoepitopes according to their ability to elicit an immune response are key elements of the project.

Perspective:
Cancer immunotherapy, which focuses on the deliberate use of the patient’s immune system to fight cancer, has demonstrated tremendous promise in the clinic. A particularly interesting strategy are personalised vaccines based on tumour-specific neoepitopes. However, pre-clinical approaches require time-consuming screening steps to identify neoepitopes, and current in silico (computational) tools for efficient neoepitope identification are scarce and of limited accuracy.

Kontakt

Lars Rønn Olsen
Gruppeleder, Lektor
DTU Sundhedsteknologi
45 25 24 25