PhD scholarship in Formulation of Drug Delivery Systems for Antibiotics

fredag 29 nov 19

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Frist 15. januar 2020
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A PhD studentship is available within Development of Drug Delivery Systems for Antibiotics.

The section for Biotherapeutic Engineering and Drug Targeting invites applicants for a fully funded 3-year PhD position in formulation of drug delivery systems for antibiotics.

Bacterial infections are becoming increasingly problematic in terms of antibiotic resistance. Localized infections (e.g. osteomyelitis, diabetic foot ulcers and valvular endocarditis) represent major challenges in modern healthcare and alternative solutions are warranted to improve therapeutic efficacy and reduce risk of developing antibiotic resistance. The current treatment regime is, in many cases, based on long term systemic administration of antibiotics, which is often impaired by a poor bioavailability or formation of bacterial biofilms.         

The current project entails design and testing of novel biocompatible biomaterials for local sustained delivery of antibiotic combinations. These formulations will be injectable and form positionally depots at the site of injection. Prodrug strategies for improved bioavailability and reduced toxicity are considered part of the project.  

The CBIO group is a multidisciplinary research environment covering the interface between the life sciences and physical sciences with particular emphasis on biomaterials and biological interfaces. The CBIO group has a strong focus on translational research bringing projects from the early stage of material synthesis to formulation and further into preclinical testing.

The fully funded 3-year PhD student will pursue the following interdisciplinary projects:
 

  • Develop biomaterials for sustained release of antibiotic combinations.
  • Evaluate antibiotic formulations in cell cultures and mini-organs.
  • Evaluate antibiotic drug delivery systems across multiple animal models.
The project will be conducted in collaboration with the Novo Nordisk Foundation Center for Biosustainability, DTU and Department of Veterinary and Animal Sciences, Section for Pathobiological Science, KU.

Responsibilities and tasks
The candidate will create material technology for formulation of current antibiotics and prodrugs. The candidate will work as part of a team of scientists within the CBIO group and external collaborators. Willingness to work in an international environment is essential. The successful applicants must demonstrate the following: 
  • A strong background in the physical sciences, preferably with a Master degree in chemistry/physical chemistry/biophysics, analytical chemistry or related topics (e.g. pharmacy, chemical engineering, material science, bionanotechnology etc.). Experience of relevant life sciences (e.g. cell biology, physiology etc.) is a bonus, but not essential.
  • Experience with biophysical characterization of liquid, gel and solid materials, and a basic knowledge of how such materials interact with tissue.
  • The ability to work both independently and in a team within interdisciplinary fields.
  • A high degree of personal motivation.
  • Creative and critical thinking skills.
  • Excellent communication skills in English (oral and written).
The PhD candidate should be able to start Q2 of 2020; however, the state date can be flexible for the right candidate.

Qualifications
Candidates should have a two-year master's degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master's degree.

Approval and Enrolment
The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see the DTU PhD Guide

Assessment
The assessment of the applicants will be made by Professor Thomas L. Andresen, Senior Researcher Anders E. Hansen and Associate Professor Jonas R. Henriksen.

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and appointment terms
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed with the relevant union. The period of employment is 3 years.  

The student will be based at DTU Health Technology, DTU Lyngby Campus.

You can read more about
career paths at DTU here

Further information
Further information may be obtained from Associate Professor Jonas R. Henriksen, email: jhen@dtu.dk; tel: +45 4058 2866. 

You can read more about DTU Health Technology on
www.healthtech.dtu.dk/english

Application
Please submit your online application no later than 15 January 2020 (local time)Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:
  • A letter motivating the application (cover letter)
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and Excel spreadsheet here)
Candidates may apply prior to obtaining their master's degree but cannot begin before having received it.

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

DTU Health Tech engages in research, education, and innovation base on technical and natural science for the healthcare sector. The Healthcare sector is a globally expanding market with demands for the most advanced technological solutions. DTU Health Tech creates the foundation for companies to develop new and innovative services and products which benefit people and create value for society. DTU Health Techs expertise spans from imaging and biosensor techniques, across digital health and biological modelling, to biopharma technologies.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 11,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. Our main campus is in Kgs. Lyngby north of Copenhagen and we have campuses in Roskilde and Ballerup and in Sisimiut in Greenland.