2 PhD scholarships in Super-Resolution Microscopy of Nanoparticles

onsdag 11 mar 20

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Frist 1. maj 2020
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Two 3-year PhD scholarships are available at DTU Health Tech within the SuperCol project in the groups for “Nanofluidics and Bioimaging” (Project 1) and “Stochastic Systems and Signals” (Project 2). Starting dates are between July 1 and October 1, 2020.

SuperCol establishes a unique and well-structured training network with leading R&D labs from European universities and industry within correlative microscopy and colloidal sciences. 15 PhD students will form an interdisciplinary research team that will bridge the gap between various disciplines and unite their research efforts to advance particle-based biomedical applications.

The SuperCol project is supported by the European Union's
Horizon 2020 research and innovation programme
Marie Sklodowska-Curie Innovative Training Networks (ITN) under grant No. 860914. 

About the project
Colloidal particles are micro- or nanoscopic particles whose surfaces can be functionalized. Their large surface-to-volume ratio ensures that one can load each one with many molecules to deliver and release drugs or bind pathogens and biomarkers at a target site, opening potential for powerful diagnostic and therapeutic systems. To unlock this potential, however, one needs to combine super-resolution microscopy, colloidal sciences, and advanced modelling to (a) control, (b) visualize and quantify, and (c) rationally design surface-functionality.

You will work towards this goal by designing and applying reliable optical super-resolution methods that can resolve the individual active sites on the particles with nanometer-resolution, which currently is not possible. In
Project 1, you will focus primarily on experiments combining nanofluidics and super-resolution optical microscopy, while in Project 2, you will focus primarily on the theoretical and data-analytical aspects. 

The projects will be jointly supervised by Rodolphe Marie, Kim Mortensen, and Henrik Flyvbjerg at DTU Health Tech. 

Responsibilities and tasks
As PhD-students in these projects, you will work closely together towards a common goal, but each of you will be responsible for independently carrying your own research project. You will be enrolled in the PhD school at DTU Health Technology and be a part of the ITN SuperCol. 

Specifically, as a PhD student in
Project 1, you will be part of the Nanofluidics and Bioimaging group led by Associate Professor Rodolphe Marie. We expect that you: 
  • will be responsible for performing single fluorophore microscopy with applications in colloidal sciences and life science.
  • work with laser optics, fluorescence microscopy, quantitative biophysics measurement of single fluorophores and nanoparticles, and possibly prototyping of micro- and nanofluidics devices.
  • apply data analysis methods on your microscopy data in collaboration with the PhD student in Project 2.
  • collaborate with researchers and PhD students working in one industry partner of the ITN, Blusense A/S, based in Denmark.
  • are fluent in English (oral and written).
  • have good collaborative skills and will contribute to the pleasant working environment in the group and in the department.
As a PhD-student in Project 2, you will be part of the group for Stochastic Systems and Signals and you will 
  • have the responsibility for developing and testing theoretical and data-analytical methods for optical super-resolution microscopy of nanoparticles.
  • use data analysis of microscopy images as input to optimize both your algorithms and the experiments that produced them, also in collaboration with the PhD student in Project 1.
  • perform analytical and numerical calculations of image formation.
  • provide input to the design and optimization of particle-based biomedical systems.
  • engage in an international, interdisciplinary, and collaborative environment.
  • mentor and inspire junior team members such as bachelor and master students.
To be successful in this line of work, we expect that you 
  • are enthusiastic and motivated for doing research at the interface between super-resolution microscopy and colloidal sciences.
  • have a solid base in optical physics, microscopy, and/or data analysis with strong analytical skills.
  • have experience with computer programming (Python, MatLab, or similar).
  • are fluent in English (oral and written).
  • have good collaborative skills and will contribute to the pleasant working environment in the group and in the department.
Qualifications
Candidates should have a two-year master's degree (120 ECTS points) in physics, nanotechnology, or a related discipline or a similar degree with an academic level equivalent to a two-year master's degree. 

The vacancy is open to candidates who are in the first four years (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree (Eligibility rule), and who have not resided or carried out their main activity (work, studies, etc.) in Denmark for more than 12 months in the 3 years immediately prior to your recruitment (Mobility rule). 

Approval and Enrolment
The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see the DTU PhD Guide

Assessment
The assessment of the applicants will be made by the team of supervisors. Final assessment will be based on an interview. 

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility. 

Salary and appointment terms
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years.

Your workplace will be DTU, Kongens Lyngby Campus, Denmark.

You can read more about
career paths at DTU here

Further information
Further information may be obtained from Rodolphe Marie, email: rcwm@dtu.dk, tel.: +45 4525 5676; Kim Mortensen, email: kimo@dtu.dk, tel.: +45 4525 6309; or Henrik Flyvbjerg, email: hefy@dtu.dk, tel.: +45 4525 8147.

You can read more about DTU Health Tech at
www.healthtech.dtu.dk

Application
Please submit your online application no later than 1 May 2020 (local time)
Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include: 
  • A letter motivating the application (cover letter). This should also indicate which of the two projects you are applying for.
  • Curriculum vitae
  • Grade transcripts and BSc/MSc diploma (see below)
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and Excel spreadsheet here)
Candidates may apply prior to obtaining their master's degree but cannot begin before having received it.

Applications and enclosures received after the deadline will not be considered.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply. 

DTU Health Tech engages in research, education, and innovation base on technical and natural science for the healthcare sector. The Healthcare sector is a globally expanding market with demands for the most advanced technological solutions. DTU Health Tech creates the foundation for companies to develop new and innovative services and products which benefit people and create value for society. DTU Health Techs expertise spans from imaging and biosensor techniques, across digital health and biological modelling, to biopharma technologies. The department has a scientific staff of about 175 persons, 130 PhD students and a technical/administrative support staff of about 80 persons.

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DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 11,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. Our main campus is in Kgs. Lyngby north of Copenhagen and we have campuses in Roskilde and Ballerup and in Sisimiut in Greenland.