Alex Sanz Perez

PhD project by Alez Sanz Pérez

Name: Alex Sanz Pérez
Project Title: Optimization of adoptive cell transfer in the preclinical setting: development of an in vivo imaging system
Thomas L. Andresen and Anders E. Hansen

Project description:
The scope of this PhD project is to genetically engineer murine T cells for subsequent non-invasive in vivo imaging following adoptive transfer into a mouse. An imaging transgene developed in the lab of Professor Sanjiv Sam Gambhir at Stanford University, CA, US will be used to track T cells through fluorescence, bioluminescence, and PET scanning. To do so, a stable transduction of T cells with a second-generation lentiviral system as well as the CRISPR-Cas9 technique will be performed.

Overall, the successful completion of this PhD project will allow for a thorough analysis of T cell kinetics, and how these are affected by the immune-gels or nanoparticles, enabling the validation of such cancer immune therapies. Ultimately, this will add great value to a high number of ongoing and prospective research projects in the group.


Alex Sanz Pérez
DTU Sundhedsteknologi


Thomas Lars Andresen
Institutdirektør, professor
DTU Sundhedsteknologi
25 37 44 86


Anders Elias Hansen
DTU Sundhedsteknologi
45 25 81 39