Nanna Wichmann Larsen

PhD project by Nanna Wichmann Larsen

Name: Nanna Wichmann Larsen
Project Title: Development of high-throughput peptide-screening assays for oral drug delivery
Group: Colloids & Biological Interfaces
Supervisor(s): Thomas L. Andresen, Kasper Kristensen and Jens Bæk Simonsen

Project Description:
The main object of this project is to study peptides, particularly their in-solution properties, their membrane-activity, and their propensity to cross a membrane. To do this, medium-throughput biophysical methods for studying (modified) peptides will be developed. The methods will mainly include different light-based techniques such as scattering and fluorescence. The properties will be studied to screen peptides for which peptides to use for in vivo studies, aiming for peptides able to translocate across the epithelial layer of the small intestines.

Perspective:
Peptides as drugs is of increasing focus. The advantages of peptide drugs over small molecule drugs are the versatility of peptides for target recognition and their high target specificity. However, the ability of the peptides to translocate across membranes and thus be taken up is often limited by the hydrophilic nature of the peptides. Consequently, most marketed peptide drugs are currently not available as easy-to-swallow tablets, but are rather delivered in less compliant ways, such as through injections. By investigating membrane interaction properties of peptides, it should be possible to determine properties that enable the translocation, and the mechanism by which the membrane translocation takes place. In combination, this should benefit to the field of delivering peptide drugs as an easy-to-swallow tablet.

Kontakt

Nanna Wichmann Larsen
Ph.d.-studerende
DTU Sundhedsteknologi
45 25 81 66

Kontakt

Thomas Lars Andresen
Institutdirektør, professor
DTU Sundhedsteknologi
25 37 44 86

Kontakt

Kasper Kristensen
Forsker
DTU Sundhedsteknologi
45 25 81 66

Kontakt

Jens Bæk Simonsen
Gæst
DTU Sundhedsteknologi