Stine Egebro Hansen

PhD project by Stine Egebro Hansen

Name: Stine Egebro Hansen
Project Title: Microcontainers for improved biofilm treatment
Group: Drug delivery and Sensing (IDUN)
Supervisors: Line Hagner Nielsen and Anja Boisen

Project Description:
Lung infections with Pseudomonas aeruginosa are difficult to eradicate as it forms biofilm protecting the bacteria. Inhaled powdered antibiotics have the limitation that they distribute in all areas of the lungs and a certain degree of dilution takes place. Micrometer sized polymeric containers (microcontainers) have been developed for oral delivery of therapeutics and studies have shown that the microcontainers are engulfed by the intestinal mucus. This property might also apply to the biofilm. The focus of this PhD is to study the microcontainers interaction with the biofilm and to create a system with a controlled release kinetic of antibiotics at the site of infection hence providing an improved treatment.

Perspective:
Biofilms are implicated in virtually every human infections. An example is the lung disease cystic fibrosis in which 80% of deaths result from severe pulmonary infections. Knowledge about the interaction between the microcontainers and the biofilm obtained in this project will not only be useful for treatment of cystic fibrosis but also in the treatment of other infectious diseases.

Kontakt

Kontakt

Line Hagner Nielsen
Lektor
DTU Sundhedsteknologi
45 25 57 51

Kontakt

Anja Boisen
Sektionsleder, Professor
DTU Sundhedsteknologi
45 25 57 27