Juliane Fjelrad Christfort

PhD project by Juliane Fjelrad Christfort

Name: Juliane Fjelrad Christfort
Project Title: Evaluating microcontainers for oral delivery of probiotics
Group: Drug Delivery and Sensing (IDUN)
Supervisor(s): Line Hagner Nielsen, Kinga Zor and Anja Boisen

Project Description:

Prebiotics and probiotics are applied to affect the human microbiota of the gut, for example with the purpose of preventing diarrhea. Probiotics are typically delivered orally in the form of tablets containing spray-dried bacteria, but key challenges remain. These include targeted delivery of microorganisms to the lower part of the small intestine and into the mucus layer to multiply and colonize in the gut mucosa. Recently, micrometer sized polymeric cylindrical containers (known as microcontainers) have been developed for oral delivery of therapeutics. Studies have shown that microcontainers spontaneously adhere to the intestinal mucus, which makes microcontainers promising for targeted delivery of probiotics. The focus of this PhD is to develop and apply physiologically relevant models that can be used for in vitro, ex vivo, in situ or in vivo evaluation of microcontainers loaded with probiotics.

Perspective:

The human body contains a multitude of bacteria, which exceeds the number of human cells.  The microbiota of the gut interacts with the human immune and endocrine systems and plays a role in diseases like diabetes, cancer and autism. Many mechanistic studies suggest that probiotics play a role in prevention and treatment of a variety of diseases. Detailed knowledge about the interplay between probiotics, microcontainers and the mucus layer can be very useful for treatment of intestinal diseases like for example inflammatory bowel disease.

Kontakt

Juliane Fjelrad Christfort
Ph.d.-studerende
DTU Sundhedsteknologi

Kontakt

Line Hagner Nielsen
Lektor
DTU Sundhedsteknologi
45 25 57 51

Kontakt

Kinga Zor
Seniorforsker
DTU Sundhedsteknologi
45 25 57 51

Kontakt

Anja Boisen
Sektionsleder, Professor
DTU Sundhedsteknologi
45 25 57 27