Salime Bazban-Shotorbani

PhD project by Salime Bazban-Shotorbani

Name: Salime Bazban-Shotorbani
Project Title: Bioinspired Targeted Polymeric Nanomedicines for Atherosclerosis Therapy
Group: Bioinspired nanomaterials
Supervisor: Nazila Kamaly

Project Description:
The object of this project is to engineer a novel microfluidic platform to resemble atherosclerosis-on-a-chip under blood flow and shear stress. This microfluidic platform can mimic the physiological environment of vessels in order to test various nanomedicines, along with atherosclerosis relevant inflammatory molecules. Our aim is to recruit organs-on-chips science and technology to fabricate a screening and testing platform for various anti-atherosclerotic nanomedicines, with the view of gaining mechanistic insight into their adhesion, translocation, transmigration or receptor-mediated uptake under inflammatory conditions.

Atherosclerosis is an inflammation driven chronic disease of the arteries, whereby cholesterol accumulates in the arterial wall leading to the build-up of atherosclerotic plaques. This life-treating disorder is the major cause of cardiovascular disease (CVD), which is the leading cause of death worldwide – causing 40% of all mortality in Western societies. Therefore, there is a growing need for development of new drugs and drug delivery systems for diagnosis, prevention, and treatment of this number one killer disease. Consequently, there is a need for an efficient drug-testing technology. Typical drug-testing systems such as two-dimensional cell cultures cannot fully recapitulate in vivo conditions. On the other hand, animal models are poor predictors of human responses. Moreover, animal tests are lengthy and costly. To overcome the shortcomings of common testing systems, we have proposed to use organ-on-a-chip technology for atherosclerotic nanomedicine studies and screening.