Super resolution imaging - SRI

Super resolution ultrasound imaging (SRI) is a new groundbreaking method enabling a true leap in diagnosis of cancer and diabetes. It can potentially attain a 10 micrometer resolution by using ultrasound tracking of contrast agents and opens a whole new and exciting field for

investigating human microvascular physiology and diagnostics. The project, supported by Innovation Fund Denamrk, translates SRI from experimental 2-D imaging of immobilized rodents, to human clinical use in full 3D.

The project partners develop new silicon based probes and 3D printed ultrasound phantoms (this research is done by the MEMS group), a new flexible scanner architecture, imaging and motion estimation schemes, and conducts human trials on cancer and diabetes patients. This makes it possible to introduce new, inexpensive 3D imaging schemes based on a new flexible software scanner and advanced silicon based probes on the market. These are used for SRI and 3D abdominal ultrasound imaging with a full 3D visualization of flow with the potential of radically improving vascular imaging, cancer staging and diabetes quantification.

The aim of the SRI project is to create a proof of concept prototype of a super resolution ultrasound imaging scanner able to detect, visualize, quantify, and assist in diagnosing the microvasculature of tissue and lesions, both malignant and benign in realistic models in a preclinical trial.

The role of the MEMS group in this ongoing project is research and development of RCA CMUT probes for use both in rodents and humans and the 3D printed flow phantoms needed for calibration.