Research

Development of Advanced Nanobiosensor for Rapid and Sensitive Detection of Multiple Contaminants in Food (NADEC)

Figure 1.  The nanobiosensor includes a disposable plastic cartridge and a handheld instrument. A new class of nanoparticle-based receptor is developed to simultaneously possess magnetic, fluorescence, bioaffinity and barcoding properties. The sample concentration chamber contains a 3D structure. When the food sample flows through the sample concentration chamber, the target analytes are captured by the nanoparticles. The binding event induces an optical signal which will be detected by the SAF micro-lens array in the detection chamber.

The nanobiosensor includes a disposable plastic cartridge and a handheld instrument. A new class of nanoparticle-based receptor is developed to simultaneously possess magnetic, fluorescence, bioaffinity and barcoding properties. The sample concentration chamber contains a 3D structure. When the food sample flows through the sample concentration chamber, the target analytes are captured by the nanoparticles. The binding event induces an optical signal which will be detected by the SAF micro-lens array in the detection chamber.

Enhanced, Plasmon-Induced Resonance Energy Transfer (PIRET)-mediated Photothermal and Photodynamic Therapy Guided by Photoacoustic and Magnetic Resonance Imaging

 

We developed a PIRET-mediated nanoplatform for enhanced, imaging-guided phototherapy. Prussian blue (PB) was incorporated into Au@Cu2O nanostructure, and assembled with poly(allylamine) (PAH) modified black phosphorus quantum dots to form Au@PB@Cu2O@BPQDs/PAH nanocomposites. The hybrid nanosystem exhibited great absorption in NIR region, as well as the ability to self supply O2 by catalyzing hydrogen peroxide and convert O2 into singlet oxygen (1O2) under 650 nm laser light (0.5 W/cm2) irradiation. In vitro and in vivo assay showed that the generated heat and toxic 1O2 from Au@PB@Cu2O@BPQDs/PAH nanocomposites could effectively kill the cancer cells and suppress tumor growth. Moreover, the unique properties of PB modified nanosystem allowed for synergistic therapy with the aid of T1-weighed magnetic resonance imaging (T1-weighted MRI) and photoacoustic imaging (PAI).