Tailored Materials and Tissues

  • Functional materials
  • Microphysiological systems
  • Additive manufacturing
  • Tissue engineering
  • Bioprinting

We develop new functional materials and fabrication methods for engineering the interphase between living and artificial.

Stem cell-based microphysiological systems and organs-on-chips aim to recapitulate the structure and function of native human tissue within an artificial microsystem, to create new opportunities for drug screening, personalized medicine and disease modelling in vitro. Next generation systems aspire to interphase the tissue models with sensory and bioactive materials. Focusing on cardiac and skeletal muscle tissues, we are integrating flexible electronic materials into living tissue models, for providing continuous and scalable data acquisition and stimulation.

Additive manufacturing has opened new opportunities not only for rapidly creating 3-dimensional parts, but also for integrating multiple materials into complex assemblies. Bioprinting research aspires to assemble cells and biomaterials into fully functional living tissues for in vivo and in vitro purposes. Focusing on extrusion-based printing of engineered inks, we are integrating functional materials with living matter, to generate synthetic tissues with unique in-built modalities.

 

Interested in a PhD position, bachelor or master thesis project?

Contact: joli@dtu.dk

 

Selected and recent publications:

Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip,

M. Yadid, J.U. Lind, H.A.M. Ardoña , et al.

Science Translational Medicine, 2020, 12 (565)

 

Large-scale spontaneous self-organization and maturation of skeletal muscle tissues on ultra-compliant gelatin hydrogel substrates, J.H. Jensen, S.D. Cakal, J. Li, C.J. Pless, C. Radeke, M.L. Jepsen, T.E. Jensen, M. Dufva J.U. Lind*, Scientific Reports, 2020, 10, 13305

 

3D-Printed Soft Lithography for Complex Compartmentalized Microfluidic Neural Devices,

J. Kajtez, S. Buchmann, S. Vasudevan, M. Birtele, S. Rocchetti, C.J. Pless, A. Heiskanen, R.A. Barker, A. Martínez-Serrano, M. Parmar, J.U. Lind*, J. Emnéus, Advanced Science, 2020, 7, 2001150

 

Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing
J.U. Lind, T.A. Busbee, A.D. Valentine, et al., Nature Materials, 2017, 16, pp: 303-308

Phototactic navigation in a tissue engineered Soft-robotic Ray
S-J. Park, M. Gazzola, K.S. Park, S. Park, V. Di Santo, E.L. Blevins, J.U. Lind, et al., Science, 2016, 353, pp: 158-162

Cardiac microphysiological devices with flexible thin-film sensors for higher-throughput drug screening
J.U. Lind, M. Yadid, I. Perkins, et al., Lab on a Chip, 2017, 17, pp: 3692-3703

JetValve: Rapid manufacturing of biohybrid scaffolds for biomimetic heart valve replacement
A.K. Capulli, M.Y. Emmert, F.S. Pasqualini, D. Kehl, E. Caliskan, J.U. Lind, et al., Biomaterials, 2017, 133, pp: 229–241.

 

Key Funding:

DFF Sapere Aude 

MSCA-IF

Lundbeck Foundation

 

 


 

 

 

 

Contact

Johan Ulrik Lind
Group Leader, Associate Professor
DTU Health Tech