PhD project by Sarantos Mantzagriotis

Name: Sarantos Mantzagriotis
Project Title: Investigating novel-pulse shapes through computational modelling of the electrode-neuron interface and psychophysics experiments
Group: Hearing Systems
Supervisors: Jeremy Marozeau and Bastian Epp

Project Description: 
A major limitation in Cochlear Implantation (CI) is the spread of current excitation induced by each electrode, resulting in a reduced efficiency between the electrical pulse and auditory nerve responses. This current spreading mis-activates neuronal populations of the auditory nerve resulting in poor frequency resolution, dynamic range, and distortion of the original acoustical signal. It is hypothesized that currently used rectangular pulses, are far from optimal for maximizing information transmission within the neural-electrode interface.

Perspective:
The project aims at improving pitch discrimination and musical perception in CI by optimizing in-silico, pulse shapes and stimulation strategy parameters. Initially, it will investigate this by creating a computational framework that couples phenomenological neuronal models, based on animal experimentation, with 3D cochlear electrical conduction models. The framework will then be extended to investigate collective neuronal behavior based on  population models, combining feedback from psycho-acoustical experimentation.

Contact

Sarantos Mantzagriotis
PhD student
DTU Health Tech

Contact

Jeremy Marozeau
Groupleader, Associate Professor
DTU Health Tech
+45 45 25 47 90

Contact

Bastian Epp
Groupleader, Associate Professor
DTU Health Tech
+45 45 25 39 53