PhD project by Wentao Wang

Name: Wentao Wang
Project Title: Synthesis and Characterization of Self-Oxygenated Nanoparticles for Cancer Therapy
Group: Nanomaterials and Nanobiosensors
Supervisor: Yi Sun

Project Description:
It is found that the tumor­associated antigens generated in situ after photodynamic therapy (PDT), photothermal therapy (PTT), chemotherapy, radiotherapy (RT), and starving-like therapy could show vaccine­like functions, which in combination with checkpoint blockade could induce strong anti­tumor immune responses for effective cancer immunotherapy. We try to develop a new type of nanoagent to prevent tumor growth by combining starving therapy/PDT/PTT with checkpoint­blockade immunotherapy. In my project, the immunoadjuvant can enhance retention responding to the acidic tumor microenvironment and further target cancer cells.

Perspective:
This biodegradable, multifunctional NPs enhance cellular internalization and tumor retention and efficiently target the tumor sites, thereby improving imaging and therapeutic effects. In combination with PD­L1 checkpoint blockade will ablate primary tumors directly and suppress distant tumors via activating strong anti­cancer immune responses. With these efforts, this project will develop a multimodal nanoagent with synergistic treatments and imaging functions, addressing the profound challenges in cancer therapy and diagnostics.