Wentao Wang

PhD project by Wentao Wang

Name: Wentao Wang
Project Title: Synthesis and Characterization of Self-Oxygenated Nanoparticles for Cancer Therapy
Nanomaterials and Nanobiosensors
Supervisor: Yi Sun

Project Description:
It is found that the tumor­associated antigens generated in situ after photodynamic therapy (PDT), photothermal therapy (PTT), chemotherapy, radiotherapy (RT), and starving-like therapy could show vaccine­like functions, which in combination with checkpoint blockade could induce strong anti­tumor immune responses for effective cancer immunotherapy. We try to develop a new type of nanoagent to prevent tumor growth by combining starving therapy/PDT/PTT with checkpoint­blockade immunotherapy. In my project, the immunoadjuvant can enhance retention responding to the acidic tumor microenvironment and further target cancer cells.

This biodegradable, multifunctional NPs enhance cellular internalization and tumor retention and efficiently target the tumor sites, thereby improving imaging and therapeutic effects. In combination with PD­L1 checkpoint blockade will ablate primary tumors directly and suppress distant tumors via activating strong anti­cancer immune responses. With these efforts, this project will develop a multimodal nanoagent with synergistic treatments and imaging functions, addressing the profound challenges in cancer therapy and diagnostics.



Yi Sun
Groupleader, Associate Professor
DTU Health Tech
+45 26 67 39 98