Rolf Bech Kjeldsen

PhD project by Rolf Bech Kjeldsen

Name: Rolf Bech Kjeldsen
Project Title: Imaging of Microcontainers Used for Oral Drug Delivery
Group:
Drug Delivery and Sensing (IDUN)
Supervisor(s):
Anja Boisen, Line Hagner Nielsen and Kinga Zór

Project Description:
In this project, setups for gastrointestinal imaging of microcontainers are being developed. This includes in vitro and ex vivo testing before being able to carry out in situ and in vivo studies in rats or pigs. Among the biomedical techniques used are magnetic resonance imaging, ultrasound imaging and x-ray imaging. To ensure a visible image signal from the microcontainers, contrast agents are typically needed. Such contrast agents can be either manually loaded into the core of the microcontainers or they can be incorporated into the microcontainer shell during fabrication.

Perspective:
In general, microcontainers have shown promising results when it comes to oral administration of drugs and vaccines due to for example their mucoadhesive and unidirectional drug release properties. Therefore, it is of great interest to understand their gastrointestinal behavior even better through easy and fast visualization. As an example, visualization can provide information on where the microcontainers adhere to the intestinal mucus layer and when their pH sensitive lid dissolves. These are both very important parameters when considering release and absorption of drugs.

Figur Rolf Kjeldsen

Contact

Rolf Bech Kjeldsen
Guest
DTU Health Tech

Contact

Anja Boisen
Head of Sections, Professor
DTU Health Tech
+45 45 25 57 27

Contact

Line Hagner Nielsen
Group leader, Associate Professor
DTU Health Tech
+45 45 25 57 51

Contact

Kinga Zor
Senior Researcher
DTU Health Tech
+45 45 25 57 51