PhD project by Philip Hassing Ronøe Carlsen

Name: Philip Hassing Ronøe Carlsen
Project Title: Microcontainers for oral delivery of vaccines
Group: IDUN
Supervisors: Anja Boisen, Line Hagner Nielsen and Dennis Christensen 

Project Description: 
The focus of this project is to evaluate the ability of so-called Microcontainers, to deliver vaccines orally. The Microcontainers are developed at DTU in the IDUN group, and has shown great promise in delivering drugs through the oral route. The advantages of these containers are that, release of the vaccine is controlled through polymeric lids with different properties. In addition, they imbed themselves into the mucus, which retains the vaccine in the intestine, and thereby prolongs the absorption time. In the project we will also explore, potential potent mucosal adjuvants supplied by Staten Serum Institute, and methods that can prolong the stability and shelf life of vaccines. 

Today most vaccines are administered with needles. This is a very invasive method, which requires trained personal and is time consuming when vaccinating large crowds. In addition, vaccines needs to be kept at low temperatures at all times, from production to patient, which is costly. Circumventing these issues could benefit both patients, to be administered easy through the oral route and quickly, and the production companies, to save money on storage and transportation. 


Anja Boisen
Head of Sections, Professor
DTU Health Tech
+45 45 25 57 27


Line Hagner Nielsen
Group leader, Associate Professor
DTU Health Tech
+45 45 25 57 51