Advanced biomaterial implants for diagnostics and therapy

The CBIO group develops advanced biomaterials that can assist in diagnostics and therapeutic interventions. Positionally and chemically stable markers with X-ray contrast for computed tomography (CT) imaging have been developed to provide guidance during image-guided radiation therapy and proton beam therapy for cancer. These have undergone full development from bench to bedside and are now marketed for use in the clinic after trials in esophageal, bladder, and non-small cell lung cancer. Moreover, novel materials with visibility in a range of important clinical imaging modalities (PET, CT, near-infrared imaging) are being developed for surgical guidance. Projects are ongoing to create multifunctional biomaterials capable of providing mechanical support, while simultaneously releasing antibiotics or tissue growth factors in a controlled manner for application in wound healing and tissue regenerative therapy. In addition, embedding of radionuclides into advanced biomaterials are made to expand upon the potential application and efficacy of localized brachytherapy or use of these as markers in image guided and robotic surgery. One strategy to enable this is by embedding hydrophobic complexes of beta-emitters (177Lu or 90Y) to increase focal radiation dose in tumors, while limiting damage to the surrounding tissue.

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Jonas Rosager Henriksen
Head of Section, Associate Professor
DTU Health Tech
+45 40 58 28 66

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Thomas Lars Andresen
Professor
DTU Health Tech
+45 25 37 44 86

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Anders Elias Hansen
Senior Researcher
DTU Health Tech
+45 45 25 81 39

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Carl Fredrik Melander
Researcher
DTU Health Tech
+45 45 25 81 32

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Linda Maria Bruun
Researcher
DTU Health Tech
+45 26 49 68 95

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Gael Clergeaud Veiga
Researcher
DTU Health Tech
+45 45 25 81 35