Biomimetics, Biocarriers and Bioimplants (The 3Bs)

The research at “The 3Bs” group is intrinsically interdisciplinary and it involves the convergence of materials science and chemistry together with cell and molecular biology, which is an exciting frontier for scientific development that holds promise for significant advances in human health.

Our research aims to create advanced, high-performance materials for therapeutic delivery and regenerative medicine using biologically inspired paradigms.

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Research

The 3Bs research directions consist of developing carriers as an advanced platform for combinatorial therapy, as microreactors to conduct biological reactions (the so-called artificial cells) or for the controlled delivery of growth factors for tissue engineering.

The research at “The 3Bs” group is intrinsically inter-disciplinary and it involves the convergence of materials science and chemistry together with cell and molecular biology, which is an exciting frontier for scientific development that holds promise for significant advances in human health.

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Blood Substitutes

Blood transfusions, which mainly rely on the administration of isolated red blood cells (RBCs), are a well-established procedure employed to replenish blood loss during following a traumatic injury, during surgery and for the treatment of diseases such as chronic anaemia, haemophilia or for patients undergoing chemotherapy. Unfortunately, blood transfusions have also important limitations which include i) a limited supply with a worldwide acute shortage; ii) the need for typing and matching before it can be transfused due to the RBC membrane antigens, causing fatal delays in emergency situations; iii) their short storage lifetime, which makes it impossible to create large stockpiles to be used when man-made or natural disasters occur (e.g., earthquakes, plane accidents); iv) or the fact that RBCs cannot be sterilized to remove infective agents, such as hepatitis viruses or HIV, and prevent spreading of newly emerging pathogens.

Therefore, research efforts have focused in developing RBC substitutes that circumvent the aforementioned drawbacks. RBCs substitutes have: i) unlimited availability, ii) display compatibility with all blood types, thus avoiding the need for cross matching, iii) long-term shelf-life and iv) lack of disease transmission since they can be prepared in sterile conditions

At The 3Bs, we develop haemoglobin-based oxygen carriers to be used as an “oxygen bridge” when donor blood is not available.

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Publications

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Information for Future Students and Researchers

 

MSc and BSc Projects

MSc and BSc projects are available. If you are interested, please contact Leticia Hosta-Rigau.

Erasmus/visiting students

Incoming students are welcome to contact us. If interested, please send a copy of (i) academic transcripts (grades) and (ii) a CV and (iii) a short summary of practical lab experience indicating the amount of independent lab work.

Postdoc and Marie Curie Opportunities

Postdocs

Interested candidates please contact Leticia Hosta-Rigau indicating which grants do you intend to apply for to cover a postdoc in the group.

Outstanding candidates, i.e. candidates trained in very strong research environments and/or with an excellent publication record in top journals may get funding support and/or help in writing applications.

Please provide (i) a cover letter (ii) a CV and list of publications, (iii) a brief summary of research experience (max two pages).

Marie Curie Individual fellowships

Candidates that align with all requirements of the Marie Curie program may get support in compiling an application. Please contact Leticia Hosta-Rigau for details.

Contact

Leticia Hosta-Rigau
Groupleader, Associate Professor
DTU Health Tech
+45 45 25 81 55