PhD project by Yupeng Zhao

Name: Yupeng Zhao
Project Title: Hyperpolarized Water for MR Angiography and Perfusion
Group: Hypermag 
Supervisors: Jan Henrik Ardenkjær‐Larsen , Lars G. Hanson, Rie Beck Olin

Project Description: 
With this project we will explore the potential for hyperpolarized MR to overcome the fundamental sensitivity limitations in angiography and perfusion, and create a novel MR contrast agent based on water. The research will extend the hyperpolarization technology to fast relaxing nuclei like the 1H, which will have general implications in MR imaging and NMR spectroscopy. In this project, we will develop the MR methods for coronary MR angiography and quantitative perfusion imaging with hyperpolarized water.

Perspective:
Recently, the European Medicines Agency (EMA) issued a recommendation to suspend three widely used magnetic resonance imaging (MRI) contrast agents (CAs) that are Gadolinium (Gd)-bearing CAs (GBCA), and the U.S. Food & Drug Administration (FDA) has required new class warnings for these agents. Due to this background, the scientific community seeks radically new alternatives. Secondly, Gadolinium (Gd) based contrast agents change the contrast in the image, but does not increase the available signal. Therefore only moderate improvement in image quality has been seen over past many years. Water could be the ultimate contrast agent with minimal safety concerns. To achieve this goal we need to hyperpolarize a bolus of water to give hundred-fold enhanced NMR signal. We will do this by the dissolution-DNP method. The proposed method can enhance the signal 10,000-fold and thereby enable coronary angiography within a single cardiac cycle, which is currently not possible with MR; or enable quantitative perfusion.

Kontakt

Yupeng Zhao
Ph.d.-studerende
DTU Sundhedsteknologi

Kontakt

Jan Henrik Ardenkjær-Larsen
Konstitueret Institutdirektør, Professor
DTU Sundhedsteknologi
45 25 39 18

Kontakt

Lars G. Hanson
Gruppeleder, Lektor
DTU Sundhedsteknologi
45 25 36 86

Kontakt

Rie Beck Olin
Postdoc
DTU Sundhedsteknologi