PhD project by Signe K. Skadborg

Name: Signe K. Skadborg
Project Title: Immunophenotyping and neoepitope mapping in relation to immunotherapy of cancer
Group: T cells and cancer 
Supervisor: Sine Reker Hadrup

Project Description: 
Cancer immunotherapy has shown great clinical results and especially checkpoint inhibitors (CPIs) has been a major contributor to the success. We are assessing the cellular response in patients who receives immune therapy in two ongoing clinical trials. We are looking into samples from (1) patient with recurrent Glioblastoma treated with CPI and (2) patients with melanoma treated with a personalized peptide vaccine together with CPI. We are following their immune composition in blood and tumor over the course of treatment as well as detecting T cells specific for neoantigens using new technology developed in our laboratory.

Investigating the effect of immune therapy on a cellular level is of great importance. It can help us to understand the clinical outcome on a deeper level and it can point us in the right direction in the way to find optimal therapy for the individual patient.


Signe Koggersbøl Skadborg
DTU Sundhedsteknologi


Sine Reker Hadrup
Sektionsleder, Professor
DTU Sundhedsteknologi
35 88 62 90