Milan Wesseler

PhD project by Milan Wesseler

Name: Milan Finn Wesseler
Project Title: 3D Oxygenation of Thymic Organoids
Group: Engineered Fluidics and Tissues
Supervisor: Niels Bent Larsen

Project Description:
The main objective of this project is to develop thymic organoid constructs with precisely engineered oxygen tensions through high resolution 3D printing of microfluidic PEGDA chips. The long-term biological aim is to achieve T-cell maturation facilitated by a functional thymus-on-a-chip with thymic cortical and medullary regions.

Thymic organoids will be an important tool for disease modelling, understanding of T-cell maturation, and for the generation of patient specific T-cells for cell-based immunotherapy. In addition, the platform may be used for cancer disease models and chemotherapeutic agent testing, where precise oxygen gradients are needed.


Niels Bent Larsen
Sektionsleder, Professor
DTU Sundhedsteknologi
45 25 81 61