PhD project by Giorgia Moranzoni

Name: Giorgia Moranzoni
Project Title: The myeloproliferative neoplasms as a model for cancer immunoediting: an inquiry into the coevolution of cancer and immune cells
Group: Single Cell Omics
Supervisor: Lars Rønn Olsen 

Project Description: 
The objective of this project is to learn the rules governing the coevolution of cancer
and immune cells in patients with myeloproliferative neoplasm (MPN), which is characterized by a gradual exhaustion of tumor-specific immune cells despite strong in vitro activity, and leverage this knowledge to modulate immunotherapy towards a curative outcome. The aim is to explicitly model the coevolution of tumor and immune cells by analyzing single cells from blood and bone marrow of MPN patients who participated in a phase I vaccination trial. 

Perspective:
The features of the disease, the vaccine trial, the rigorous sampling of tissues, and the analyses planned in this project together produce a controlled system which we believe we can use to create the first ever in vivo model of tumor and immune cell interaction dynamics.

Contact

Giorgia Moranzoni
PhD student
DTU Health Tech

Contact

Lars Rønn Olsen
Groupleader, Associate Professor
DTU Health Tech
+45 45 25 24 25