Katrine Jönsson

PhD project by Katrine Jønsson

Name: Katrine Jønsson
Project Title: Development of an intratumoral vaccine technology with sustained release of immunogenic anti-cancer peptides and adjuvants
Group: Colloids & Biological Interfaces (CBIO)
Supervisors: Thomas Lars Andresen, Anders Elias Hansen and Ditte Elizabeth Jæhger 

Project Description: 
This PhD project revolves around optimizing cancer treatment by the use of immunogenic anti-cancer peptides and adjuvants. A gel-based vaccine technology with a sustained release of antigens and immune stimulatory adjuvants will be developed to circumvent the need for chemo- or radiotherapies as a source of antigen. The focus is on development of a vaccine technology including loading of antigens and immune stimulatory drugs, release studies, and biological evaluation of the drug delivery system in preclinical cancer models. 

Perspective:
The therapeutic effect of already existing immunotherapies, primarily check point inhibitors, appears to be limited to immunogenic tumors, which comprise only a small group of all tumors. This vaccine technology has the potential of reinvigorating the anti-cancer immune response by local, intratumoral delivery of antigens and adjuvants and thereby circumvent the need for e.g. chemo- or radiotherapy.  

 

Contact

Katrine Jønsson
PhD student
DTU Health Tech

Contact

Thomas Lars Andresen
Professor
DTU Health Tech
+45 25 37 44 86

Contact

Anders Elias Hansen
Senior Researcher
DTU Health Tech
+45 45 25 81 39

Contact

Ditte Elisabeth Jæhger
Postdoc
DTU Health Tech