PhD project by Marcus Göransson

Name: Marcus Göransson
Project Title: The impact of neo‐epitope recognition in NSCLC
patients treated with immune‐checkpoint inhibition
Group: T cells and cancer
Supervisors: Sine Reker Hadrup and Sunil Kumar Saini 

Project Description: 
The field of immunotherapy has grown rapidly for the last decade, rendering new questions. As a tumor grow, the tumor cells accumulate mutations, generating  novel tumor-specific antigens, referred to as neo-antigens which can be detected by the immune system. The main objective of this project is to identify neo-antigen recognizing T cells, how immunotherapy affect the T cell repertoire, and evaluate the neo-antigen recognizing T cells function and phenotypic profile, in the setting of non-small-cell lung carcinoma (NSCLC).

Perspective:
By improving the knowledge of how the T cell repertoire is affected by immunotherapy, and what role they play in fighting cancer, we advance in the field of immunotherapy, and can better adapt and personalize cancer treatment in the future.

Contact

Marcus Göransson
PhD student
DTU Health Tech

Contact

Sine Reker Hadrup
Head of Sections, Professor
DTU Health Tech
+45 35 88 62 90

Contact

Sunil Kumar Saini
Assistant Professor
DTU Health Tech
+45 35 88 68 07