Name: Xin Li
Project Title: Optimizing solid cancer treatment with local immono-gel injection with immunostimulatory drugs
Group: Colloids & Biological Interfaces (CBIO)
Supervisors: Thomas Lars Andresen, Lars Ringgaard Petersen and Gael Clergeaud Veiga
Project Description:
This PhD project is focused on optimizing cancer treatment with immunostimulatory drugs formulated in liposomes for sustained drug delivery and further exploit it as a vaccination platform in combination with adoptive T‐cell therapy.The PhD project will primarily focus on the development of the drug delivery system, optimizing the encapsulation of immunostimulatory drugs into liposomes to obtain controllable delivery systems with fast/slow drug release properties that will impact their biological effect in vivo. After the formulation optimization and in vitro testing, we will investigate the in vivo anticancer efficacy of the liposomes as vaccination platforms with adoptive T‐cell therapy.
Perspective:
This project aims to prove anticancer efficacy in preclinical studies on murine models of the developed liposomes, both as monotherapy but also as liposomal vaccination platforms to potentially improve the outcome of therapeutic cancer vaccines.