PhD scholarship in Modeling Directed Motion of Nanoparticles in the Eye with Laser Light

Monday 19 Sep 22

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Apply no later than 24 October 2022
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Starting 1 December 2022 (or shortly thereafter), the Technical University of Denmark (DTU), Department of Health Technology is offering a PhD position in nanoparticle transport with optical methods.

Research project
Chronic diseases of the retina and optic nerve (CDRON) result in irreversible vision loss and eventual blindness, affecting millions of people worldwide. Treatment involves direct injection of large quantities of drugs into the vitreous humor, but most of the drugs never reach the retina at the back of the eye due to the flow that runs from the back to the front of the eye. So efficient treatment requires frequent injections, which is not without risk to the eye (e.g, inflammation) and often results in poor patient compliance.

We will lay the theoretical foundation for pushing nanoparticles over centimeter-long distances against a flow for targeted treatment in ocular drug delivery. Your overall focus will be to explore and model different physical transport mechanisms for moving nanoparticles in both uniform and structured media, e.g., in gels, with laser light. These transport methods must be compatible with eye physiology and not be harmful to the eye. Key elements in the modelling will include laser beam shaping, diffusive/advective nanoparticle transport, heating of the medium, and eye biology.   

Responsibilities and qualifications
We seek a highly motivated student, and preferably with a degree in physics, optics, applied mathematics, material science, or bioengineering. The ideal candidate should be interested in analytical calculations, numerical simulations (using, e.g., finite-element software), and analysis of data from experimental collaborators.

Relevant competences could, e.g., include:

  • Physical modelling
  • Optical methods, e.g., beam shaping
  • Theoretical (micro)fluidics
  • Experience with finite-element software
  • Analysis of experimental data

The project will be supervised by Associate Professor Jonas N. Pedersen at DTU Health Tech and co-supervised by Associate Professor Andrew Urquhart (DTU Health Tech).

You must have a two-year master's degree (120 ECTS points) or a similar degree with an academic level equivalent to a two-year master's degree.

Approval and Enrolment
The scholarship for the PhD degree is subject to academic approval, and the candidate will be enrolled in one of the general degree programmes at DTU. For information about our enrolment requirements and the general planning of the PhD study programme, please see DTU's rules for the PhD education

Assessment
The assessment of the applicants will be made by Associate Professor Jonas N. Pedersen and Assoc. Prof. Andrew Urquhart.

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.


Salary and appointment terms
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years. Starting date is 1 December 2022 (or shortly thereafter). The position is a full-time position.

You can read more about career paths at DTU here.

Further information
Further information may be obtained from Associate Professor Jonas N. Pedersen (jnpe@dtu.dk).

You can read more about DTU Health Tech at www.healthtech.dtu.dk, and about Associate Professor Jonas N. Pedersen at https://bit.ly/3RJO7gb.

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark. Furthermore, you have the option of joining our monthly free seminar “PhD relocation to Denmark and startup “Zoom” seminar” for all questions regarding the practical matters of moving to Denmark and working as a PhD at DTU.

Application procedure
Your complete online application must be submitted no later than 24 October 2022 (Danish time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

  • A cover letter (max 500 words)
  • Curriculum vitae (max 2 pages): degrees with dates and place must be clearly stated; only relevant previous work experience must be stated; you should state the contact information of at least two academic referees, one of which must be the project supervisor of your MSc thesis.    
  • A one-page summary of your MSc thesis.
  • Two reference letters, one of which must be from the project supervisor of your MSc thesis.     
  • Grade transcripts and BSc/MSc diploma.

Incomplete applications will not be considered. You may apply prior to ob­tai­ning your master's degree but cannot begin before having received it.

Applications received after the deadline will not be considered.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

DTU Health Tech
DTU Health Tech engages in research, education, and innovation base on technical and natural science for the healthcare sector. The Healthcare sector is a globally expanding market with demands for the most advanced technological solutions. DTU Health Tech creates the foundation for companies to develop new and innovative services and products which benefit people and create value for society. DTU Health Tech’s expertise spans from imaging and biosensor techniques, across digital health and biological modelling, to biopharma technologies. The department has a scientific staff of about 210 persons, 140 PhD students and a technical/administrative support staff of about 160 persons, of which a large majority contributes to our research infrastructure and related commercial activities.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear vision to develop and create value using science and engineering to benefit society. That vision lives on today. DTU has 13,400 students and 5,800 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.