Qing Tang

PhD project by Qing Tang

Name: Qing Tang
Project Title: Effective 125I-IUdR Drug Delivery Via Nanocarriers for GBM Cancer Treatment
Group: Targeted Radionuclides
Supervisor: Andreas Tue Ingemann Jensen

Project Description: 
This project aims to deliver 125I-IUdR to human brain via nanocarriers. Selected carriers, such as liposomes and micelles, will be loaded with 125I-IUdR and its lipophillized derivatives. These loaded nanoparticles will then be administered to GBM-rats through convection-enhanced delivery (CED). These injected nanoparticles also have larger sizes than free 125I-IUdR, so they can stay in the brain tissue for a longer time after CED, and the loaded 125I-IUdR will release slowly over time and be taken up by cancer cells, ultimately achieving the goal of killing the infiltrating cancer cells. 

Perspective:
This project prepare a useful and highly biocompatible nano-delivery system for 125I-IUdR in brain and evaluate its therapeutic effects both in vitro and in vivo. In contrast to free 125I-IUdR, nanocarrier assisted 125I-IUdR will have prolong retention time, which ensures that they are not rapidly cleared by brain flow, thus enabling the effective release of 125I-IUdR. It is expected that this designed nanoplatform will provide high activation/radiation efficiency for cancer therapy.

Kontakt

Qing Tang
Ph.d.-studerende
DTU Sundhedsteknologi

Kontakt

Andreas Tue Ingemann Jensen
Gruppeleder, Seniorforsker
DTU Sundhedsteknologi
46 77 53 62