Rolf Bech Kjeldsen

PhD project by Rolf Bech Kjeldsen

Name: Rolf Bech Kjeldsen
Project Title: Imaging of Microcontainers Used for Oral Drug Delivery
Group:
Drug Delivery and Sensing (IDUN)
Supervisor(s):
Anja Boisen, Line Hagner Nielsen and Kinga Zór

Project Description:
In this project, setups for gastrointestinal imaging of microcontainers are being developed. This includes in vitro and ex vivo testing before being able to carry out in situ and in vivo studies in rats or pigs. Among the biomedical techniques used are magnetic resonance imaging, ultrasound imaging and x-ray imaging. To ensure a visible image signal from the microcontainers, contrast agents are typically needed. Such contrast agents can be either manually loaded into the core of the microcontainers or they can be incorporated into the microcontainer shell during fabrication.

Perspective:
In general, microcontainers have shown promising results when it comes to oral administration of drugs and vaccines due to for example their mucoadhesive and unidirectional drug release properties. Therefore, it is of great interest to understand their gastrointestinal behavior even better through easy and fast visualization. As an example, visualization can provide information on where the microcontainers adhere to the intestinal mucus layer and when their pH sensitive lid dissolves. These are both very important parameters when considering release and absorption of drugs.

Figur Rolf Kjeldsen

Kontakt

Rolf Bech Kjeldsen
Ph.d.-studerende
DTU Sundhedsteknologi

Kontakt

Anja Boisen
Sektionsleder, Professor
DTU Sundhedsteknologi
45 25 57 27

Kontakt

Line Hagner Nielsen
Lektor
DTU Sundhedsteknologi
45 25 57 51

Kontakt

Kinga Zor
Seniorforsker
DTU Sundhedsteknologi
45 25 57 51