PhD project by Line Wulff Christensen

Name: Line Wulff Christensen
Project Title: Heterogeneity in Human Intestinal Mononuclear Phagocytes
Group: Mucosal Immunology
Supervisor(s): William Agace and Lars Rønn Olsen

Project Description:
Mononuclear phagocytes can be found in many tissues in the human body. In each tissue these cells can adapt their functionality and can be identified based on different patterns of protein expression. This project is focused on the subgroup of mononuclear phagocytes called dendritic cells, here with special focus on plasmacytoid dendritic cells an classical dendritic cells 1 and 2. With this project we aim to uncover the differences in function and abundance of these subsets of dendritic cells both between effector and lymphatic tissues of the human gut. Furthermore, we want to compare all of the above between healthy tissue and Crohn’s disease.

Perspective:
Inflammatory bowel diseases such as Crohn’s disease are highly debilitating diseases. Within the mononuclear phagocyte compartment abundance and proportions of some subsets are known to change during inflammation. Mononuclear phagocytes, especially the dendritic cells, are acknowledged to play a crucial role in bridging between the innate and the adaptive immune defence. With this and previous studies in mind it has been proposed that the mononuclear phagocytes play an important role in these diseases. With this project we hope to uncover some of the differences both in abundance but also on a transcriptomic level in the mononuclear phagocytes during Crohn’s disease. This knowledge might open up for better treatment options and understanding of the disease.

 

Kontakt

Line Wulff Christensen
Ph.d.-studerende
DTU Sundhedsteknologi

Kontakt

William Winston Agace
Gruppeleder, Professor
DTU Sundhedsteknologi
35 88 68 99

Kontakt

Lars Rønn Olsen
Gruppeleder, Lektor
DTU Sundhedsteknologi
45 25 24 25