PhD project by Jeppe Sejerø Holm

PhD project by Jeppe Sejerø Holm

Name: Jeppe Sejerø Holm
Project Title: Towards accurate prediction of T cell targests: Learning the rules of T cell receptor interaction
Group: T-cells & Cancer
Supervisor: Sine Reker Hadrup

Project Description:
The main objective of this project is to investigate how T-cell receptors bind to peptide antigens targets and to characterise this interaction on a molecular level. The governing factors of how T-cells highly selectively interact with antigens, both self- and cancer antigens, are largely unknown. Using high-throughput methods, which enables investigating more than 1000 potential T-cell-antigen interactions simultaneously, the rules regarding T-cell receptor binding preferences can be characterised in-depth. Uncovering these principles will aid to further understand detection and recognition of cancer-derived antigens by T-cells.

Perspective:
Immunotherapy has been shown to be highly effective towards multiple cancer types compared to traditional chemotherapy. Understanding T-cell receptor binding preferences – and cross-reactivity to unwanted target – is key in the development of safe immunotherapies, such as T-cell receptor gene therapy and Adoptive cell therapy, and bringing these to the clinic.

 

 

Kontakt

Jeppe Sejerø Holm
Gæst
DTU Sundhedsteknologi

Kontakt

Sine Reker Hadrup
Sektionsleder, Professor
DTU Sundhedsteknologi
35 88 62 90